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KMID : 1033120120010010061
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대한비만대사외과학회지
2012 Volume.1 No. 1 p.61 ~ p.65
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Durability of the Effect of Proximal Intestinal Bypass Surgery on Glucose Tolerance Improvement: A Pilot Study in Zucker Diabetic Fatty Rats
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Kim Young-Mi
Ahn Su-Min
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Abstract
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Purpose: DJB has been shown to ameliorate type2 diabetes in rodents and in short-term clinical studies. We sought to characterize the effect of DJB on glycaemia control and its durability in longitudinal study.
Materials and Methods: ZDF rats aged 18 weeks randomly underwent DJB, sham-operation with pair-feeding (PF) and sham operation with ad-libitum feeding (AL). Body weight (BW) and food intake (FI) were measured daily. Longitudinal sequential tests of fasting glycemia and oral glucose tolerance test (OGTT) were performed periodically up to 12 weeks after surgery.
Results: DJB animals decreased in FI immediate postoperatively and recovered to preoperative level 4 weeks after surgery. There were no differences in BW among groups throughout the study period. DJB animals showed greater GT than PF and AL groups at 2 weeks after surgery (AUC-OGTT2wk; 39,736±1,100 vs. 50,501.±1,171 vs. 44,602±829 mg/dl*min, respectively; P=0.012). However, 4 weeks after surgery GT deteriorated in DJB rats and became similar to controls. At 12 weeks after surgery GT in DJB rats became similar to baseline (P>0.05) and better than controls (AUC-OGTT, 45,790±1,987 vs. 52,250±1,416 vs. 54,311±2,918, respectively; P=0.041). Fasting glycemia and glucose challenge-2hr glycaemia in DJB were significantly lower than in controls at 2 and 12 weeks after surgery.
Conclusion: DJB leads to early improvement of glycemia in ZDF rats, an effect which appears to be weight-independent. This longitudinal study, however, showed an attenuation of the glucose lowering effect over time in ZDF rats.
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KEYWORD
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Type2diabetes, Duodenojejunal bypass, Glucose tolerance, Duarability
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